Glutathione Wiki

Glutathione has been shown to:

• Be a Powerful Antioxidant
• Fight Free Radicals
• Improve Cardiovascular Health
• Reduce Oxidative Stress
• Help Control Inflammation
• Detoxify the Liver and Cells
• Reduce Effects of Aging
• Aids in Mental Clarity
• Improves Sleep
• Increases Energy

Glutathione!

Integr Med (Encinitas). 2014 Feb; 13(1): 8–12.

PMCID: PMC4684116

PMID: 26770075

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684116/

Joseph Pizzorno, ND, Editor in Chief

Forman HJ, et al (2009). Glutathione: overview of its protective roles, measurement, and biosynthesis.

Sekhar RV, et al. (2011). Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation.

Links:

Glutathione supplementation suppresses muscle fatigue induced by prolonged exercise via improved aerobic metabolism

Glutathione-Your Body's Miracle Molecule

Every cell in your body is assaulted by destructive agents such as free radicals, chemical toxins, heavy metals and radiation that damage the cell, inhibit optimum function and accelerate the aging process and the onset and progression of the diseases and issues associated with aging. Glutathione is the master protector of the cell and defends the cell from these destructive agents.

Over 180,000 scientific studies and articles on Glutathione are recorded in PubMed, the official U.S. Government library of medical research. Those articles reveal the remarkable role glutathione plays in the protection and function of every cell in the human body and the support of optimal health and function. They also show the terrible consequences of low glutathione levels, and how those lower levels accelerate the aging process and increase vulnerability to the issues of aging.

People With Higher Glutathione Levels:

• Have More Energy

• Recover Faster From Exercise

• Sleep Better

• Have Greater Mental Clarity and Focus

• Less Inflammation

• Improved Joint Function

• Have Better Immune Systems

• Live Longer

• Live Better

• Improve the Health and Function of Every Cell, Tissue and Organ in the Body

Glutathione

Is Your Body's Master Antioxidant

It is considered the master antioxidant due to its unique multifunctional characteristics as well as it's unprecedented ability to neutralize many types of free radicals that assault the cell. It is the only antioxidant that recycles itself again and again to continue fighting free radicals.

Is The Primary Detoxifier of the Cell

Today we are confronted by over 80,000 chemicals in the air we breathe, the food and water we ingest, and the materials we touch and handle. Many of these toxic chemicals enter our cells and must be eliminated to protect the cell and maintain optimum function. Glutathione is the cell's first line of defense against chemicals and toxins and the primary detoxifier that can eliminate many of these toxins when it is present in optimal amounts.

Is A Powerful Chelator of Heavy Metals

Heavy metals enter our cells in the same manner as chemical toxins. Fortunately, they can be removed from the cell by a process of chelation, and Glutathione is one of the cell's most powerful chelating agents.

Is The Protector of the Immune Cell

Our immune cells are designed to protect us, but what protects the immune cell? Glutathione is the protector of the immune cell and allows newly formed immune cells to proliferate to attack germs and viruses.

Is The Protector of Mitochondrial DNA

The breakdown of the mitochondrial DNA accelerates aging and increases cell death. Glutathione is the protector of the Mitochondrial DNA, and the lower the glutathione level, the more vulnerable this DNA becomes to breakage.

Is The Protector of the Nucleus of the Cell

The nucleus of the cell regulates all cell activity and protecting it is critical to the health of the cell and its optimal function. When present in abundance, glutathione gives the nucleus the protection it needs.

Reduces Oxidative Stress

Oxidative Stress is the most aggressive destructive force that assaults the cell. Cells manufacture a number of antioxidants to counter oxidative stress. Glutathione plays a primary role in neutralizing many different types of free radicals.

Reduces Intercellular Inflammation

Inflammation is the mortal enemy to the tissues, organs and various systems of the body. All inflammation begins at a cellular level, and low glutathione levels are associated with inflammation.

Is “The Re-Utlizing” Agent of Ingested Antioxidants

Antioxidants that are ingested (not manufactured by the body such as vitamin C and E) once spent, cannot be re utilized by the cell unless they are first converted into a usable state. Glutathione is the agent that converts those antioxidants into a state that can be utilized by the cell.

Reducing Agent for Hemoglobin, allowing it to Transport Oxygen to Every Cell.

The purpose of hemoglobin is to carry oxygen to all living cells. However, when it is oxidized, it cannot carry an oxygen molecule and must first be reduced to an acceptable state. Glutathione protects hemoglobin from oxidizing agents and can also make this possible

.

PROBLEM-Your Glutathione Levels are Decreasing, But the Attacks on Your Cells are Not!

The continued exposure to toxins, free radicals, radiation, and heavy metals can lower our levels of glutathione. This continued exposure causes cells to lose their optimum function. As the cells are damaged, the aging process and all of its issues accelerate. Energy levels fall, inflammation levels increase and all of the cells, tissues and organs pay the price. On top of this, injuries, infections and diseases further deplete glutathione levels.

Glutathione: A Favorite Among Athletes

• Glutathione is popular among athletes as it reduces oxidative stress in the body, enabling it to combat free radicals that can impact endurance and athletic performance.
• It enhances the body's response to muscle soreness, aiding in muscle recovery and swift return to peak performance.
• Acting as an antioxidant coenzyme, glutathione is derived from glutamic acid, cysteine, and glycine, playing a crucial role in eliminating free radicals and tissue repair.
• Benefits for Athletes:
• Enhanced Endurance and Performance: Glutathione helps in improving physical exercise endurance and boosting energy levels during demanding athletic activities.
• Reduced Muscle Soreness and Inflammation: By aiding in muscle recovery, glutathione minimizes downtime due to soreness, allowing athletes to maintain their fitness routines.
• Faster Recovery Time: Quick recovery is vital for athletes, and glutathione supports energy production, facilitating faster bounce-back after workouts.
• Improved Immune System Function: Glutathione contributes to a robust immune system, crucial for maintaining peak athletic performance.
• Research and Case Studies:
• Glutathione supplements have been proven safe and effective for athletes, with studies indicating enhanced lean mass and reduced oxidative stress without adverse effects.
• Further research highlights the effectiveness of glutathione in reducing muscular damage and degenerative issues in elite athletes.

The American Brain Council is a non-profit foundation focused on informing the public of practical evidence based insights which when applied can improve brain health and cognitive abilities, and thus reduce the risk for dementia, depression and other related cognitive decline.

We have noted that glutathione is essential to brain health, and can reduce the risk for cognitive decline through at least 7 different pathways.

1. By reducing blood sugar levels, abdominal fat and damage to vital proteins in the brain. Some of the best documented contributors to cognitive decline are insulin resistance (diabetes), and resulting high blood sugar levels and fat accumulation, which can damage proteins and impair signaling critical to brain health and function. Oxidative stress contributes to insulin resistance, and as noted above GSH suppresses that, but it also exerts a more direct effect on insulin resistance and protects against blood sugar damage to these vital proteins. Researchers at Baylor School of Medicine found in a study of older individuals, that higher glutathione levels were associated with less insulin resistance, higher fat burning and lower rates of fat storage in the body.2 Another study found that boosting glutathione levels not only lowered oxidative stress but the damage resulting from uncontrolled diabetes, even despite high sugar levels.
   
2. .By reducing oxidative stress in the body and brain. Oxidative stress has been found to be an early event and major contributor to age-related cognitive decline. Glutathione(GSH)isthe premier suppressor of oxidative stress, reactive oxygen species, or what we call free radicals, in the body and the brain.
   
3. By facilitating detoxification in the body and brain. Unfortunately there are a growing number of environmental toxins, like mercury, aluminum, lead, molds, Lyme disease, insecticides, industrial toxins, and more than 200 medications that can adversely affect our nervous system and brain , either directly or indirectly. Glutathione is the master detoxifier in our body, reducing the effects of these toxins on our brain and DNA, and extinguishing the associated inflammation (also known to impair brain function), and ushering the exit of these toxins from our body.
   
4. By protecting the production of energy required by our brain. The brain is a super high energy consumer. It requires more energy than any other organ in the body, except the heart. And when it can’t get the energy it needs it slows down and becomes less functional. For optimal energy and focus our bodies and brains require an abundance of mitochondria and a wealth of glutathione to protect them from the free radicals they produce in that process. Free radicals necessitate the anti-oxidative effects of glutathione to prevent mitochondrial damage and mutations to its DNA.4 As noted above they also protect brain cells and their mitochondria from other neurotoxins as well.
   
5. By improving blood flow to the brain. Both macro and micro vascular Blood flow is critical to brain health. If that flow is impaired the brain will not be able to acquire the oxygen and nutrients it needs to function optimally. GSH has been shown to help protect arteries from damage, inflammation and plaque formation, but it also increases hemoglobin affinity for oxygen,5 and it can help to relax blood vessels, allowing from greater blood flow. It’s no wonder that in a 2002 study from the Mayo Clinic, they found that patients with peripheral artery disease showed significant improvements in both macro and micro-circulatory parameters following intravenous glutathione twice per day, and their pain-free walking distance improved. Also great for the brain!
   
6. By reducing the effects of stress and injuries on the brain. Prolonged stress increases cortisol in the brain which, over time can damage cells in the hippocampus, the memory center of the brain. Traumatic brain injuries (TBI), of course, can also damage brain cells. Moreover, a study at Oregon State University found that when levels of glutathione become depleted, in older animals, they died twice as fast when subjected to stress. However, when pretreated with GSH their cells did not die near a quickly.7 Other anecdotal reports from individuals who have suffered concussions and TBI’s suggests glutathione may accelerate recovery from such injuries.
   
7. By improving sleep and reducing the effects of sleep deprivation on the brain. Sleep is critical for brain health. And sleep deprivation decreases GSH levels and can impair learning and memory. However, higher glutathione levels may improve sleep. In one study, it was found that those who had increased levels of glutathione were able to fall asleep easier at night and wake up more refreshed in the morning. Moreover, it was found that the body is able to naturally produce more glutathione when the quality and duration of sleep were increased.
   
8. Since glutathione is so important to brain health, and Swish 30 has been shown, through a variety of evidences, to enhance the delivery of glutathione into brain cells, the American Brain Council has elected to endorse this product.
   

A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition...

• Alzheimers Dis. 2015;45(2):395-405. doi: 10.3233/JAD-142499. https://www.ncbi.nlm.nih.gov/pubmed/25589719?dopt=Abstract
  
• Correcting glutathione deficiency improves impaired mitochondrial fat burning, insulin resistance in aging. https://www.bcm.edu/news/geriatrics/glutathione-deficiency-fat-insulin-aging
  
• Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine. Journal of the American Diabetes Association. http://care.diabetesjournals.org/content/34/1/162
  
• Mitochondria and Glutathione – Behind the Scenes of Aging and Disease, Holtorf Med Group. https://www.holtorfmed.com/mitochondria-and-glutathione-behind-the-scenes-of-aging-and-disease/
  
• Molecular Medicine September 2001, Volume 7, Issue 9, pp 619–623 https://link.springer.com/article/10.1007/BF03401868
  
• Effect of Glutathione Infusion on Leg Arterial Circulation...https://www.mayoclinicproceedings.org/article/S0025-6196(11)62019-3/abstract
  
• Redox Biol. 2016 Dec;10:45-52. https://www.lifeextension.com/Magazine/2017/4/In-The-News/Page-01
  
• https://www.slumbr.com/blog/glutathione-naturally-sleep/
  

Glutathione acts at a cellular level in all tissues, organs, and muscles and optimizing glutathione activity is vital for achieving optimal health and superior performance.

Published studies have shown that glutathione impacts nearly every area of health and performance and aids in immune support. Recent studies have shown that increasing glutathione delays the onset and progression of fatigue—both muscularly and mentally.

What Do Medical Science Journals Say About Glutathione and Disease?

(partial list)

1 Cardiovascular

Raised glutathione levels fight the oxidation of fats circulating in the bloodstream including cholesterol, retarding the process of plaque formation in the arteries leading to most heart attacks and strokes. Nutrition Reviews 54: 1-30, 1996.

Prevents heart disease - Shimizu H, Kiyohara Y, Kitazono T, Kubo M,

Ibayashi S, Fufishima M, Lida M. Relationship Between Plasma Glutathione Levels and Cardiovascular Disease in a Defined Population: The Hisyama Study. Stroke. 2004 Sep; 35(9):2072-7.

Prevents stroke - Paterson PG, Juurlink BH. Nutritional Regulation of Glutathione in Stroke. Neurtoxicology Research 1999 Dec; 1(2): 99-112.

Prevents atherosclerosis - Coppola L, Grassia A, Giunta R. Glutathione Improves Hemostatic and Hemorrheological Parameters in Atherosclerotic Subject. Drugs Experiment Clinical Research 1992 18:493-98

2) Cancer

Glutathione plays a role in eliminating many carcinogens/acids and also maintains and optimizes white blood cell function while providing stronger anti-acidic/anti-tumor defenses. Cancer Letters 57: 91-94, 1991.

Cancer causing polychlorinated biphenyls (PCBs) have been found to alter levels of glutathione compounds in experiments, which may alter the body's resistance to certain types of cancer.

Glutathione deficiencies have been linked to many forms of cancer.

- Prevents cancerous tissue

- Suppresses tumor growth

- Eliminates carcinogen - acids

- Retards oxidative stress

- Eases side effects of chemotherapy and radiotherapy

3) Pulmonary

Doctors have used glutathione-promoting drugs to treat many lung diseases including asthma, chronic bronchitis and emphysema. New and potentially therapeutic roles can be found for cigarette smoke damage, pulmonary fibrosis and other illnesses. American Journal of Medical Science 307:119-127, 1994

Lungs - Glutathione is the most efficient free radical (acid) scavenger in the airways, and dozens of studies have confirmed that free radical (acid) damage is a primary player in Chronic Obstructive Pulmonary Disease. Rahman I, MacNee W. Oxidative Stress and Regulation of Glutathione in Lung Inflammation. European Respiratory Journal. 2000 Sep; 16(3):534-54.

Breaks up mucus - Rahman I, MacNee W. Oxidative Stress and Regulation of Glutathione in Lung Inflammation. European Respiratory Journal. 2000 Sep;16(3):534- 54

Cystic fibrosis - Glutathione neutralized harmful oxidants introduced into the lungs or those released by cells. Exotoxins from bacteria can overload the endobronchial terrain and feed the fires of acidic inflammation. This staggering burden increases the oxidative sensitivity of the CF lung, resulting in further injury of lung parenchyma. Data supports evidence of a decrease in the anitoxidant tri-peptide glutathione (Roum JH, Buhl R, McElvaney NG, et al. Systemic Deficiency of Glutathione in Systic Fibrosis. Journal of Applied Physiology 1993; 75:19-24).

Emphysema - Lamson, David, MD, Grignall, Matthew, ND. The use of

Nebulized Glutathione in the Treatment of Emphysema: A Case Report. Alternative Medicine Review. 5(5);429-431, 2000 Oct.

Pulmonary fibrosis - Ishii T, Fujishiro M, Nakajima J, Teramoto S, Ouchi

Y, Matsuse T. Depletion of Glutathion S-Transferase P1 Induces Apoptosis in Huamn Lung Fibroblasts. Experimental Lung Research. 29(7);523-36, 2003 Oct-Nov.

4) Aging

It is well known that aging is accompanied by a precipitous fall in

glutathione levels. Lower glutathione levels are implicated in many

diseases associated with aging including cataracts, Alzheimer's,

Parkinson's atherosclerosis and others. Journal of Clinical Epidemiology 47:1021-26, 1994.

Low glutathione levels have been associated with neuro-degenerative

diseases such as MS (Multiple Sclerosis), ALS (Lou Gehrig's Disease), Alzheimer's and Parkinson's. The Lancet 344: 796-798, 1994.

Parkinson's Disease - Glutathione helps to preserve brain tissue by

preventing damage from free radicals (acids) and destructive chemicals

formed by the normal processes of metabolism, toxic elements in the

environment, and as a normal response of the body to challenges by acidic agents or other stresses. With the understanding that glutathione is important for brain protection and that this protection may be lacking in the brains of Parkinson's clients due to glutathione deficiency, it can be seen as very beneficial. (Di Monte DA, Cahn P, Sandy MS. Glutathione in Parkinson's Disease: A Link Between Oxidative Stress and Mitochondrial Damage? An Neurol. 32 Suppl; S111-115, 1992.)

Alzheimer's Disease - Woltjer, R.L., Hgheim W., Maezawa I., Vaisar T,

Montine K.S., Montine T.J., Role of Glutathione in Intracellular

Amyloid-Alpha Recursor Protein/Carboxy- Terminal Fragment Aggregation and Associated Cytotoxicity. Journal of Neurochemistry. 2005 May; 93 (4): 1047-56.

Huntington's Disease - Choo Y.S., Mao Z, Johnson GV, Lesort M. Increased Glutathione Levels In Cortical Striatal Mitochondria of the

R6/2 Huntington's Disease Mouse Model. Neuroscience Letter. 2005 Sep 23; 386(1): 63-8.

Multiple Sclerosis - Calabrese V, Scapaginini G, Ravagna A, Bella R,

Butterfield DA, Calvani M, Pennisi G, Giuffrida Stella AM. Disruption of

Thiol Homeostasis and Nitrostative Stress in the Cerebrospinal Fluid of

Patients with Active Multiple Sclerosis: Evidence for a Protective Role of

Acetylcarnitine. 2003 Sep; 28(9): 1321-8. Mann CL, Davies MB, Aldersea J, Fryer AA, Jones PK, Ko Ko C, Young C, Strange RC, Hawkins CP. Glutathione S-Transferase Polymorphisms in MS: Their Relationship to Disability. Neurology. 2000 Feb 8;54(3):542-7.

ALS - Tohgi H, Abe T, Yamazaki K, Murata T, Ishizake E, Isobe C. Increase in Oxidized Products and Reduction in Oxidized Glutathione in Cerborospinal Fluid From Patients with Sporadic Form of Amyotrophic Lateral Sclerosis. Neurosci Lett. 1999 Feb 5; 260(3):204-6.

Osteoarthritis - Hammarqvist F, Luo JL, cotgreave IA, Andersson K,

Wernerman J. Skeletal Muscle Glutathione is Depleted In Critically Ill

Patients. Crit Care Med. 25(1):78-84 1997 Jan.

6) Toxicology

Toxins, Pollution and Radiation - Glutathione detoxifies a variety of pollutants, carcinogens and poisons including many found in fuel exhaust and cigarette smoke. It also retards damage from radiation exposure due to the eroding ozone layer. Annual Reviews of Biochemistry 52: 711-760, 1983

Detoxifies certain drug overdoses - Acetaminophen (Tylenolo) has been shown to reduce glutathione production, thus paving the way for enhanced brain destruction by metabolic acids. (Perlmutter D. July 2004, 5th ed:108)

Detoxifies substances in cigarette smoke and auto exhaust - Rahman I,

MacNee W. Lung Glutathione and Oxidative Stress: Implications In Cigarette Smoke-Induced Airway Disease. American Journal of Physiology. 277(6 Pt 1);1067-88, 1999 Dec.

Detoxifies pollutants including heavy metals and pesticides - Elevated

glutathione levels have been shown to protect tissue form lipid peroxidation created by exposure to certain metals. Consider infusions of glutathione to relieve the body burden of both neurotoxins and metal toxicity, including mercury. (Foster, JS. Kane PC, Speight N. The Detoxx Book. 2002;90)

7) Immunology

Anti-viral for AIDS, hepatitis, herpes, etc. - Low glutathione levels in HIV clients may contribute to their immune deficiency since glutathione plays an important role in the function of lymphocytes. Some lymphocytes require adequate levels of glutathione in order to function normally, and HIV induces oxidative stress that depletes the cells of glutathione. Townsend DM, Tew KD, Tapero H. The Importance of Glutathione in Human Disease. Biomed Pharmacother. 2003 May-June;57(3-4):145-55. Droge W, Holm E. Role of Cysteine and Glutathione in HIV Infection and other Diseases Associated with Muscle Wasting and Immunological Dysfunction. FASEB J, 11(13):1077-89 1997 Nov.

Glutathione levels correspond to poor survival of AIDS patients. Much documentation demonstrates the role of enhanced glutathione levels in AIDS. Proceedings of the National Academy of Science, USA 94: 1967-72, 1997

The liver is a major storehouse for glutathione. Glutathione is impaired in alcohol hepatitis as well as in viral (acidic) hepatitis including hepatitis A, B, and C. Raisied glutathione levels help restore liver function. American Journal of Gastroenterology 91: 2569-2573, 1996

Lyme Disease - Lyme disease is a seriously complex multi-system acidic inflammatory condition that is triggered by bacterial exotoxins. Glutathione helps to remove exotoxic and/or mycotoxic acids by forming a soluble compound with them, which can then be excreted through the urine or gut. (Can Glutathione Help Lyme Disease Suffers? Excerpt from: The Glutathione Report: Optimal Health with the Master Antioxidant, Issue 4, Volume 1, May 2004).

Chronic fatigue syndrome - An article in the Journal of Medical Hypothesis proposed that glutathione, an anitoxidant essential for lymphocyte function, may be depleted in Chronic Fatigue Syndrome patients. Glutathione is needed for both the immune system and for aerobic muscular contraction. The authors proposed that glutathione depletion by an activated immune system also causes the muscular fatigue and myalgia associated with Chronic Fatigue Syndrome (Bounous et al. 1999).

8) Metabolic

Diabetes - The blood and tissues of diabetics are marked by critically low glutathione levels. Glutathione depletion may have adverse consequences in diabetic clients independent of glycemic control, and it may weaken the defense against oxidative stress. De Mattia G, Bravi MC, Laurenti O, Cassone-Faldetta M, Armiento A, Ferri C, Falsano

F. Influence of Reduced Glutathione Infusion on Glucose Metabolism in Patients with Non-insulin Dependent Diabetes Mellitus. Metabolism. 1998 Aug;47(8):433-8.

Diabetics are more prone to 'out-fections' and circulatory problems leading to heart disease, kidney failure and blindness. Glutathione protects against the complications of diabetes. Clinical Science 91:575-582, 1996

Digestive Disorders

Glutathione protects the body from inflammation of gastritis, stomach

ulcers, pancreatitis and inflammatory bowel disease including ulcerative

colitis and Crohn's disease. Gut 42: 485-492, 1998

Kidney Disease

Those with kidney failure or on dialysis suffer from high levels of

oxidative (acidic) stress and decreased glutathione levels. Raised glutathione levels help prevent anemia. Nephron 61: 404-408, 1992

Pregnancy, Lactation and Childbirth

Glutathione's role in fetal and placental develoment is critical. It also

acts in the placenta to detoxify pollutants before they can reach the

developing child. Many complications of pregnancy have been linked with poor glutathione levels. Early Human Development 37: 167-174, 1994

Autism

Medical literature documents that an out-fection can lead to a lowering of glutathione which participates in detoxification, interacts with metallothioneins, and supports many crucial aspects of immunity. A link between glutathione and autism regression may derive from the fact that transient or chronic intestinal problems can impair an infant's or toddler's nutritional status, thereby minimizing the levels of amino-acids required for the production of glutathione (McCandless, J. Children With Starving Brains. 2003, 2nd ed; 252)

Glutathione is critically important to our brain as it is one of the most important brain antioxidants. Glutathione helps preserve brain tissue by preventing damage from free radicals (acids). In addition to quenching dangerous acids, glutathione also acts to recycle vitamin E which also has the ability to reduce acidity in the brain. (Perlmutter D., BrainRecovery.com July 2004, 5th ed:13)

Best way to supplement Glutathione

SWISH30 - NANO TECH

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Athletes using Swish30 Extra Strength have reported major improvements in physical performance, stamina and accelerated recovery. They have also reported noticeable improvements in mental focus. The Swish 30® formula is nutritional supplements. They have no known side effects. Because of their small particle sizes and the fact that they are quickly absorbed and fully utilized.

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Swish30 Extra Strength

Swish30 takes glutathione, L cysteine and curcumin and combines it with nano-technology that aids your body in recovery.

Other blog articles

unlocking Peak Performance:

The Role of Glutathione in Athletic Endurance

Speed Up Your Recovery:

How Glutathione Supports Muscle Repair Post-Workout

Breathe Easy:

Glutathione's Impact on Respiratory Health for Athletes